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Statistics

Design Of Experiments (DOE) with JMP®

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Design of experiments, or DOE, is a practical and ubiquitous approach for exploring multifactor opportunity spaces, and JMP offers world-class capabilities for design and analysis in a form you can easily use.

Methodical experimentation has many applications for efficient and effective information gathering. To reveal or model relationships between an input or factor and an output or response, the best approach is to deliberately change the former and see whether the latter changes, too. Actively manipulating factors according to a pre-specified design is the best way to gain useful, new understanding.

However, whenever there is more than one factor – that is, in almost all real-world situations – a design that changes just one factor at a time is inefficient. To properly uncover how factors jointly affect the response, you need to use design of experiments (DOE).

In addition to a complete library of tried and tested classical DOE designs, JMP also offers an innovative custom design capability that tailors your design to answer specific questions without wasting precious resources. Once the data has been collected, JMP streamlines the analysis and model building so you can easily see the pattern of response, identify active factors and optimize responses.

  • Custom Designs
  • Classical Designs
  • Other Designs
  • Optimize and Simulate
  • Split-Plot

When your goal is to create an experimental design that takes into account specific parameters like time, budget and other considerations, the unique Custom Designer in JMP constructs a design customized to your problem (using an optimal design), so you don’t have to force your problem to fit a prescribed textbook design.

The Custom Designer always makes the best use of your experimental budget. Using its computer-generated designs allows you to tackle a wide range of challenges, all within a unified framework. You can include continuous, multilevel categorical and mixture factors within the same design, and specify hard- and very hard-to-change factors for automatic creation of the appropriate split-plot, split-split and strip-strip designs.

Also, the capability to define factor constraints, model effects and interactions, as well as include center points and/or replicate runs as you build your design. Finally, the Custom Designer allows you to perform sample size and power calculations, as well as visualize alias structures all to aid you in determining whether your experimental investment is likely to be worthwhile through rich design diagnostic capabilities.

The Custom Designer allows you to builder smarter designs more quicker and efficiently to save you time, effort and make better use of your resources for conducting experiments.

The power of Custom Designs is that they are model-based. So in addition to the usual specification of factors and responses, you need to input the terms that describe the expected behavior, the shape of the opportunity space you want to explore and your budget.
The power of Custom Designs is that they are model-based. So in addition to the usual specification of factors and responses, you need to input the terms that describe the expected behavior, the shape of the opportunity space you want to explore and your budget.

Ronald Fisher first introduced four enduring principles of DOE: The factorial principle, randomization, replication and blocking. But until relatively recently, generating (and then analyzing) a design to exploit these principles relied primarily on hand calculation. Despite this burden, the ingenuity of practitioners over more than 80 years has led to a series of widely applied design families adapted to meet specific situations and experimental objectives. JMP offers all of the classical design types you would expect, including Full Factorial, Screening, Response Surface, Mixture and Taguchi Array. After defining factors and responses, JMP lets you pick an appropriate design from those listed and provides various design evaluation tools, such as prediction variance profiles and FDS plots, to assess your selection before committing any resources. Once the runs have been conducted, analysis is straightforward thanks to the pre-built JMP scripts that are stored in your data table during the design process.

Whether you use a Classical, Custom or other design, you can use the Contour Profiler to interactively probe your fitted model to see patterns of variation, visually assess how factors affect your responses and find viable operating regions.
Whether you use a Classical, Custom or other design, you can use the Contour Profiler to interactively probe your fitted model to see patterns of variation, visually assess how factors affect your responses and find viable operating regions.

Even when there is no intrinsic variability in the response, DOE still finds application in exploring highly dimensional factor spaces efficiently. To meet this situation, JMP provides Space-Filling designs, which are typically analyzed with the Gaussian Process smoother to make a surrogate model with low prediction bias and variance. JMP can also generate and analyze Choice Designs in which consumers or users are asked to state their preferences between alternatives, including price as a factor if desired. Finally, JMP provides designs for Accelerated Life Tests and Nonlinear models. And if needed, you can add more design families to JMP through its scripting language, JSL.

An example of a Choice Design analysis in JMP.
An example of a Choice Design analysis in JMP.

Although vital, design is only half of DOE. No matter which design you decide to use, JMP makes the subsequent analysis as easy as possible. Depending on the situation, the table containing your design will automatically contain the right script to analyze your results, usually via the Screening or Fit Model Platform. With multiple responses, you can simultaneously fit different models with Stepwise refinement using a chosen stopping rule. When you have built models you think are useful, The various Profilers in JMP allow you to interactively work with them and visually identify viable operating regimes and factor set points. No matter how complex your problem, The built-in Optimizer in JMP can perform the inevitable trade-off between responses with a single click. Once you have the sweet spot, you can then use the integrated Simulator to see how robust this is likely to be in practice.

The Profiler allows you to interactively probe factor space, see which factors affect the responses and how, and find optimum settings for one or more responses using desirability functions. You can also use the Simulator to assess how real-world variation will be transmitted from factors into responses.
The Profiler allows you to interactively probe factor space, see which factors affect the responses and how, and find optimum settings for one or more responses using desirability functions. You can also use the Simulator to assess how real-world variation will be transmitted from factors into responses.

Hard-to-change variables, such as the temperature of an industrial oven or the location of a cornfield, exist in the real world. A completely randomized design might require such factors to be reset with each run. Clearly, this would be impractical or cost-prohibitive. The designed experiment most appropriate for such situations is called a split plot. JMP produces I-optimal split-plot, split-split, and strip-strip designs. JMP generates the design and includes the appropriate random-effect restricted maximum likelihood (REML) model as part of the table that contains the experimental design.

An analysis of a split plot experiment with the Fit Model platform.
An analysis of a split plot experiment with the Fit Model platform.
Selected JMP capabilities in Design Of Experiments
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More resources for Design of Experiments

On-Demand Webcasts

Design of Experiments for Constrained Regions

Design of Experiments to Produce Processes That Are Robust to Supplier Variation

Designing Experiments with JMP

Design of Experiments: Mixture Designs for Formulation Scientists

Talks

Correcting Common Misconceptions about Optimal Experimental Design
Presented by Bradley Jones, PhD, at JMP Discovery Summit, Sept. 12, 2012. Introduction by Stu Hunter. (Duration: 46:06)

White Papers

Statistical Method Makes a Comeback
by Rick Mullin

Split-Plot Designs: What, Why, and How
by Bradley Jones and Christopher J. Nachtsheim

Efficient Modeling & Simulation of Biological Warfare Using Innovative Design of Experiments Methods
by Thomas A. Donnelly, Erin E. Shelly and Daniel P. Cinotti

JMP Design of Experiments (DOE)

Interactive Data Mining and Design of Experiments: The JMP® Partition and Custom Design Platforms
by Marie Gaudard, PhD, Philip Ramsey, PhD, and Mia Stephens, MS

A Class of Three-Level Designs for Definitive Screening in the Presence of Second-Order Effects
by Bradley Jones and Christopher J. Nachtsheim

Books

Statistics for Experimenters
by George E. P. Box, J. Stuart Hunter, and William G. Hunter

Design and Analysis of Experiments
by Douglas C. Montgomery

Response Surface Methodology
by Raymond H. Myers, Douglas C. Montgomery, and Christine M. Anderson-Cook

Optimal Design of Experiments
by Peter Goos and Bradley Jones

Customer Success Stories

Novomer

Almac

Dow Chemical

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More on Design of Experiments

Design of Experiments on the JMP Blog

Definitive Screening Add-In

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