Disproportionality Analysis

Running this process with the pvexample sample setting generates the tabbed Results window shown below. Refer to the Disproportionality Analysis process description for more information. Output from this process is organized into sections. Each tab contains one or more plots, data panels, data filters, or other elements that facilitate your analysis.

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Signal Summary : Summarizes drug-event pairs that had a signal from at least one of the selected disproportionality statistics, and highlights any differences among the selected statistics for generating a signal.

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Tree Map for BCPNN : Uses color and size to visually highlight the magnitude of the lower limits of the 95% credible intervals for Bayesian confidence propagation neural network (BCPNN). Estimates can be plotted instead using dialog options.

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Tree Map for MGPS : Uses color and size to visually highlight the magnitude of the lower limits of the 95% credible intervals for multi-item gamma Poisson shrinker ( MGPS ). Estimates can be plotted instead using dialog options.

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Tree Map for PRR : Uses color and size to visually highlight the magnitude of the lower limits of the 95% confidence intervals for the proportional reporting ratio ( PRR ). Estimates can be plotted instead using dialog options.

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Tree Map for ROR : Uses color and size to visually highlight the magnitude of the lower limits of the 95% confidence intervals for the reporting odds ratio ( ROR ). Estimates can be plotted instead using dialog options.

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Case Distribution : Summary of records at the case level, which includes location and any categorical or continuous strata variables .

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Adverse Event Distribution : Summary of user-specified analysis variables at the event-level. Total sample size represents all unique adverse events .

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Record Distribution : Summary of user-specified analysis variables at the record-level. Total sample size represents all drug-event pairs across all cases.

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Hierarchical for Drug : Click Hierarchical for Drug to open the Hierarchical Clustering dialog to cluster drugs with similar event patterns using the lower limits of the disproportionality statistic based on the selected cells from a Tree Map . Estimates can be clustered instead using dialog options.

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Hierarchical for Event : Click Hierarchical for Event to open the Hierarchical Clustering dialog to cluster events with similar drug patterns using the lower limits of the disproportionality statistic based on the selected cells from a Tree Map . Estimates can be clustered instead using dialog options.

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K-Means for Drug : Click K-Means for Drug to open the K-Means Clustering dialog to cluster drugs with similar event patterns using the lower limits of the disproportionality statistic based on the selected cells from a Tree Map . Estimates can be clustered instead using dialog options.

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K-Means for Event : Click K-Means for Event to open the K-Means Clustering dialog to cluster events with similar drug patterns using the lower limits of the disproportionality statistic based on the selected cells from a Tree Map . Estimates can be clustered instead using dialog options.

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Add Notes (Disproportionality Analysis) or Add Comment (depending on version): Click Add Notes or Add Comment to save a comment for drug-event pairs selected in any Tree Map .

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View Notes (Disproportionality Analysis) or View Comments (depending on version): Click View Notes or View Comments to view if comments are available for drug-event pairs selected in any Tree Map . To see all available comments, press Ctrl - A to select all tree map cells.

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Overall Bubble : Click Overall Bubble in the Plot by Event panel to display disproportionality (lower limit or estimate based on dialog option) and event frequency across all drugs reported for selected events. Alternatively, click this button in the Plot by Drug panel to display disproportionality and drug frequency across all events reported for selected drugs.

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Strata Bubble : Click Strata Bubble in the Plot by Event panel to display disproportionality (lower limit or estimate based on dialog option) and event frequency for each strata across all drugs reported for selected events. Alternatively, click this button in the Plot by Drug panel to display disproportionality and drug frequency for each strata across all events reported for selected drugs. This option is available only if one or more strata variables are provided in the dialog.

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Time Trend : Click Time Trend in the Plot by Event panel to display disproportionality (lower limit or estimate based on dialog option) across time across all drugs reported for selected events. Alternatively, click this button in the Plot by Drug panel to display disproportionality across time points for all events reported for selected drugs. Available only if an event onset date is provided in the dialog. Records with missing onset dates are not included.

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Overall Bubble Across Time : Click Overall Bubble Across Time in the Plot by Event panel to display animation of the change in event frequency and disproportionality (lower limit or estimate based on dialog option) over time, changing color as the signal criteria is met or lost. Alternatively, click this button in the Plot by Drug panel to display animation of the change in drug frequency and disproportionality over time, changing color as the signal criteria is met or lost. Available only if an event onset date is provided in the dialog. Records with missing onset dates are not included.

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dispanal.sas7bdat : Contains disproportionality estimates and 95% confidence credible intervals. time = Overall results include all records for the estimates. If strata are included, type = Within Strata highlights strata-specific estimates. Other values for time include all records up to and including the current time period for the estimates.

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Click Create Report to generate a standardized pdf - or rtf -formatted report containing the plots and charts of selected tabs.