Fit model type

Choose whether to model adverse events in a logistic model (Berry and Berry, 2004 ¹ ; Model 1b of Xia, Ma, and Carlin, 2011 ² ) or as a log-linear model adjusting for exposure time (Model 2b of Xia, Ma, and Carlin, 2011 b ).

To Choose the Model Type:

Click the radio button corresponding to your choice.

---

1

Berry, S.M., and Berry, D.A. (2004). Accounting for Multiplicities in Assessing Drug Safety:

A Three-Level Hierarchical Mixture Model. Biometrics 60 , 418-426.

2

Xia, H.A., Ma, H., and Carlin, B.P. (2011). Bayesian Hierarchical Modeling for Detecting Safety Signals in Clinical Trials. Journal of Biopharmaceutical Statistics 21 , 1006-1029.