Check this box to use an additional filter based on the magnitude of the treatment group difference (the value that is plotted on the X axis of the resulting Volcano Plots) for each statistical test when creating significant indicator variables.This filter can be used to further highlight clinically interesting results from tests found to be statistically significant. The significant indicator variables formed in the output data set is then based on both the p-value cutoff and the magnitude and direction of the treatment group difference specified using the Treatment Group Difference Cutoff parameter and Direction of the Treatment Group Difference parameter, respectively.