Add Fold Change Filter to Select Significant Tests Check this box to use an additional filter based on the fold change of Volcano Plots for statistical tests when creating significant indicator variables. An example use of this filter is to further select from tests found to be statistically significant based on fold-change or magnitude of the LSMEANS differences. The significant indicator variables formed are then based on both the p-value cutoff and the Fold Change Filter Cutoff specified below. To Add a Fold Change Filter: Check the box.