More traditional across-time displays are available using the drill-down button. The figure below shows the lower limit of the 95% credible limit for Dyspnoea, illustrating example output from this button accessed from the Plot by Event panel.
It is straightforward to see that Drug A was initially disproportional although this signal disappeared over time. However, in 2004, Drug C began showing signs of disproportionality that has continued to the present (though the lower limit is just beyond the specified signal threshold). Using dialog options, you can specify whether data is summarized annually, biannually, or quarterly, and the number of most recent time points to include for figures. Limiting the analysis to a reasonable number of recent time points can have implications on signals (since rare events might have occurred in a limited number early on) and the speed at which an analysis is generated. By default, JMP Clinical limits analyses across time to the most recent 12 time points.
The y-axis displays disproportionality while the x-axis represents time (Y indicates year, H1 is for the first half of the year, and H2 is for the second half of the year. Qx represents the first through fourth quarters). A dotted reference line highlights the limits from the Statistical Measures tab of the Disproportionality Analysis input dialog (1 for all measures, by default). Each line represents a different drug and symbol size is indicative of event frequency.
Accessed from the Plot by Drug panel, time trend plots of event signals are constructed for each of the selected drugs instead.