Major Allele Variable

The Major Allele Variable field is used to specify the variable that lists the major allelesfor each marker. If the major allele for a study does not match the major allele from the first study, the sign of the effect is switched when combining results.

To Specify the Annotation Major Allele Variable:

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Specify the Annotation SAS Data Set.

All of the variables in the specified annotation data set are displayed in the Available Variables field.

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Examine the list of available variables.

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Highlight the variable listing the major alleles.

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Click to add the highlighted variable to the Major Allele Variable field.

Note: If this variable is not specified, then computation times are increased to determine the major allele.