Type of Model
Use this parameter to select the type of model to use for testing for rare variant association.
Available models are described in the following table:
|
Select: |
When you want to: |
|
Regression-based |
Include the weighted sum method described by Madsen and Browning (2009)1; a variable-threshold approach (Price et al. 2010)2 with or without weights such as PolyPhen-2 scores; models taking the direction of the variant's effect into account, similar to Han and Pan's data-adaptive sum model (2010)3; as well as combinations of these approaches that can be put into the framework described by Hoffmann, Marini, and Witte (2010)4. |
|
KBAC |
Perform the kernel-based adaptive cluster method described by Liu and Leal (2010)5. |
|
CMAT |
Perform the cumulative minor-allele test described by Zawistowki et al. (2010)6. |
|
C-alpha |
Perform the C-alpha test described by Neale et al. (2011)7 when the trait is binary. |
To Specify the Type of Model:
| 8 | Select the desired model by clicking within the appropriate radio button. |