This tab displays
distributions
across all markers for the following heterogeneity statistics: Cochran's
Q
, the
p-value
for Cochran's
Q
, and I2 when either of the inverse
variance
methods for combining
p
-values has been selected as the
Method to Use
and an
Effect ID Variable
has been specified.
These statistics can tell you whether the fixed or
random effects
model
is appropriate for combining
p
-values for a marker. Low values of Cochran's
Q
and I
2
and a non-significant Cochran's
Q
p
-value indicate small amounts of heterogeneity between studies and thus a
fixed effects
model is likely appropriate. Otherwise, a
random effects
model should be used.
The
Local Data Filter
on the right can be used to view the distributions for a single or a subset of
chromosomes
at a time. Note however that this does not actually select markers for the drill-down buttons. Markers can be selected either by clicking on chromosomes in the legend below the plot or by selecting points in the plot using left-click with the mouse.