Select one or more methods for testing for enrichment. The method is applied separately for each significance
variable
that you specify.
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The
Fisher
Exact test first creates 0-1 variables from the significance variables based on the
Significance Variable Cutoff for Fisher Exact Tests
specified below. (If you have already specified 0-1 variables, then any cutoff between
0
and
1
works.) It then constructs 2 x 2 tables for each category and uses the hypergeometric
distribution
to compute
p-values
. Refer to the documentation of
PROC MULTTEST in SAS/STAT
for details.
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The
Cochran-Armitage
linear trend test is constructed for each variable by discretizing it into
bins
, alleviating the need for a single arbitrary significance cutoff. You can adjust the number of bins in the
Number of Bins for Cochran-Armitage Tests
specified below. Refer to the documentation of
PROC MULTTEST in SAS/STAT
for details.
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The
PAGE
test works by constructing a two-sided
z
-score for each category as described in Kim and Volsky, BMC Bioinformatics. 2005; 6: 144. The
z
-score is computed as:
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Highlight a single test, or hold down
while left-clicking on multiple tests, in the
Enrichment Tests
field.
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