LSMeans Difference Set Use this option to specify the set of LSMeans differences that you want to consider in your analysis. Available options are described in the following table: Option Definition All Pairwise Differences Choose this option to examine differences between all possible pairs of levels. Caution : Choosing All Pairwise Differences can generate numerous differences when there are many levels in your LSMeans effects. Simple Differences Choose this option to investigate all differences for which only one level has changed. Differences with a Control Choose this option to take differences against a single reference level. Important : You must specify the reference LSMeans Control Levels below. For detailed information about the files and data sets used or created by JMP Life Sciences software, see Files and Data Sets . To Specify the LSMeans Difference Set: Click the radio button corresponding to the difference set you want to use.