Add Fold Change Filter to Select Significant Tests Check this box to use an additional filter based on the fold change of Volcano Plot s for statistical tests when creating significant indicator variables . An example use of this filter is to further select from tests found to be statistically significant based on fold-change or magnitude of the LSMEANS differences. The significant indicator variables formed are then based on both the p-value cutoff and the Fold Change Filter Cutoff specified below. To Add a Fold Change Filter: Check the box.