It is possible that effects not included in your assumed model are active. In the Alias Terms outline, list potentially active effects that are not in your assumed model but might bias the estimates of model terms. The Alias Matrix entries represent the degree of bias imparted to model parameters by the effects that you specified in the Alias Terms outline. See The Alias Matrix.
By default, the Alias Terms outline includes all two-way interaction effects that are not in your Model outline (with the exception of terms involving blocking factors). Add or remove terms using the buttons. For a description of how to use these buttons to add effects to the Alias Terms table, see Model.
In the Evaluate Design platform, the Alias Matrix outline is immediately updated to reflect changes to Alias Matrix effects. In the Custom Design platform, you must click Make Design after modifying the effects in the Alias Terms outline. Within other DOE platforms that construct designs, there is no Alias Terms outline. However, the Alias Matrix outline, containing appropriate effects, appears under Design Evaluation after you construct the design.