Example of an Equivalence Test
Use the Oneway platform to investigate whether an alternative drug is not inferior to morphine for a procedure in dogs. We compare the difference in the first two time points.
1. Select Help > Sample Data Folder and open Dogs.jmp.
2. Select Analyze > Fit Y by X.
3. Select diff and click Y, Response.
4. Select drug and click X, Factor.
5. Click OK.
6. Click the Oneway Analysis red triangle menu and select Equivalence Tests > Means.
Figure 6.26 Equivalence or Noninferiority Tests Dialog
7. Select Noninferiority (One-Sided).
8. Leave the variance assumption set to Pooled Variance.
9. Set the Difference to 1. This is the noninferiority margin.
10. Click OK.
Figure 6.27 Example of a Test for Noninferiority
The observed difference in the response for the two drugs was -0.639 units. The lower bound on the confidence interval of -1.93 falls below the lower noninferiority limit of -1.0. We do not conclude that the alternative drug is not inferior to the standard drug.