Include direction of variant effect in test

Check this box to include the direction of the variant's effect (i.e. either deleterious or protective) in the model according to the sign of the correlation between the trait and variant allele counts (Han and Pan, 2010; Hoffmann, Marini, and Witte, 2010) for a regression-based model.

Note: This option is available only when Regression-based tests are specified in the Type of Model parameter.

To Specify This Option:

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Make sure that the Regression-based model is specified as the Type of Model.

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Click within the check box.