The experimental design is a Latin Hypercube. At each design point, N Runs random draws are generated with the design point serving as the center of the random draws. The shape and variability come from the specified distributions. The output has one row for each design point. The responses include the defect rate for each response with spec limits and an overall defect rate. You can use a Gaussian Process model to model the overall defect rate from the simulation experiment. For more information about Gaussian Process models, see Gaussian Process in the Predictive and Specialized Modeling book.